Investigators: Yukiko Maeda, PhD, research associate; Dutmanee Seriwatanachai, PhD,research fellow; Michael Densmore, research associate
Funder(s): NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Indian hedgehog (Ihh) has multiple functions during skeletogenesis. Mice lacking the Ihh gene exhibit severe skeletal abnormalities, including markedly reduced chondrocyte proliferation and abnormal maturation, with absence of mature osteoblasts. Since Ihh and its receptor, smoothened (smo), are expressed in chondrocytes as...
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