Clinical Sciences

Treatment of Edentulous Mandible with Implant Supported Fixed Bridges

Investigators: Goran Benic, DMD, research fellow; Muiz Mokti, DMD, implant resident; Coralie Schneider, DMD, implant resident
Funder(s):

The objective of this systematic review is to assess the long-term outcomes of fixed-implant rehabilitations for the edentulous mandible. A number of implant and prosthetic variables will be analyzed in order to determine the most suitable treatment modality for this particular clinical situation.

Splinted vs. Nonsplinted Implant Impression Techniques

Investigators: Panos Papaspyridakos, DMD, ITI fellow; Virginia Hogsett (DMD 2013)
Funder(s):

This retrospective clinical study includes 13 fully edentulous jaws, in which five to eight implants were placed in each jaw to support stress imposed by a permanent prosthesis. Implants for all patients were placed by one of two prosthodontists using a computer-guided system that standardizes the surgical procedures, as well as the placement and angulation of the implants. Two different implant impression techniques were used on each patient, one in which the abutments were splinted...

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Oral Cancer Detection Methods in a Community Setting

Investigators: Sook-Bin Woo, DMD, MMSc; Kathy Myers, RDH, MBA, project manager
Funder(s): National Institute of Dental and Craniofacial Research

The purpose of the study is to evaluate the efficiency of a risk-assessment algorithm in identifying subjects with suspicious precancerous or cancerous lesions in a high-risk population, as compared to broad screening in the general population.

Background

The Preventive Services Task Force of the United States does not recommend broad population screening of asymptomatic adults for oral cancer based on lack of...

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Duration of Behavioral Counseling Treatment Needed to Optimize Smoking Abstinence

Investigators: Christine Armour, Research Assistant; Sarah Kupper, Research Assistant
Funder(s): NIH/National Institute on Drug Abuse

Nicotine dependence is increasingly recognized as a complex and chronic condition. Only 10% to 20% of smokers receiving smoking-cessation interventions are able to maintain abstinence for one year. Poor outcomes from smoking-cessation programs may be due to the brevity and limited intensity of most existing behavioral treatments that supplement pharmacologic treatment. In our laboratory we have found very low quit rates (14%) for smokers...

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Development of an Inter-University Oral Health Research Database

Funder(s): NLM G08 grant opportunity PAR-07-236

There is a paucity of high-quality large oral-health databases that can be used to conduct research. Many dental schools in the United States, Canada, and Europe have implemented or are about to implement electronic health records (EHRs). EHRs facilitate the secure storage and retrieval of health histories, diagnoses, procedures performed, student evaluations, billin, and other administrative data. There is an unprecedented opportunity to integrate these disparate data sources that are being collected in dental...

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Complications with Implant Supported Fixed Bridges in Edentulous Patients

Investigators: Panos Papaspyridakos, DMD, ITI fellow; Marl Chen, DMD, ITI fellow
Funder(s):

The objective of this systematic review is to assess the long-term complication ratio of fixed-implant rehabilitations for edentulous patients. A number of implant and prosthetic variables will be analyzed in order to avoid preventable complications for this particular clinical situation.

A Comparison of Zirconia CAD/CAM to Conventionally Fabricated Single Implant Restorations in the Esthetic Zone: A Randomized Controlled Clinical Trial

Investigators: Ahy Linah, DMD, implantology resident; Coralie Schneider, DMD, implantology resident
Funder(s): ITI Foundation

This is a randomized clinical study with two groups of patients receiving implant restorations fabricated using two different techniques. ZirconiCa AD/CAM (ZCC) implant abutments and restorations will be compared to conventional, prefabricated titanium (TCF) implant abutments and porcelain-fused-to-metal restorations using reproducible aesthetic (objective/subjective) and biologic parameters.

Assessing Patient Safety in Dentistry

Funder(s): OHPE Department

A variety of expensive and largely ineffective methods have been used in medicine to identify AEs, including chart audits and malpractice claims review. There is little knowledge about the type and frequency of adverse events (AEs) in dentistry, with particularly a dearth of information in academic settings. The goal of this research was to 1) assess patient safety culture of faculty, hygienists, students and staff from three dental schools, 2) analyze FDA MAUDE (Manufacturer and User Facility Device Experience) database that represents device-related...

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Accuracy Outcomes of Closed-Tray and Open-Tray Impression Techniques for Bone-Level Implants: A Clinical Study

Investigators: Ahy Linah, DMD, implant resident; Connie Kim (DMD 2012)
Funder(s): Straumann

This clinical study compares the accuracy outcomes of two impression techniques, in cases where two bone-level (BL) implants are placed adjacent to each other for a multiunit bridge. In addition, the effect of implant angulations on the choice of impression technique will be assessed on stone models obtained from closed-tray and open-tray impressions. A correlation between the accuracy outcomes and the implant angulations will be sought in order...

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Role of the c-Src Proto-Oncogene in Osteoclasts

Funder(s): NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

The aim of this multiyear study is to pursue our program identifying the function of c-Src that, in the osteoclast, is required for bone resorption (src- mutants develop osteopetrosis) and is unique to c-Src (i.e., cannot be compensated by other Src family of kinases in this cell). During the first 11 years of this program, we have made very significant progress toward understanding the functions of c-Src in bone resorption. Although the mechanism(s) by which src deletion leads...

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Regulation of Osteoclastic Bone Resorption: Role of Cb1b

Funder(s): NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

In this study, we pursue our research on the molecular mechanisms of the differentiation of osteoclasts and bone resorption. The understanding osteoclast (OC) differentiation and activity has been revolutionized by the discovery that (1) the activation of RANK by RANK ligand is absolutely required for osteoclast formation and activity, and (2) stimulation of myelomonocytic precursors with M-CSF and RANK ligand is sufficient to induce the formation of OCs. Less publicized, but...

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Regulation of Osteoblast Differentiation by Delta FosB

Funder(s): NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

The purpose of this study is to further understand how DeltaFosB (DFosB) increases bone formation (BF) in adult mice. Unlike most other transcription factors involved in osteoblast (OB) differentiation, DFosB increases BF postnatally, at any point in time, while not affecting skeletal development. This mimics the desired effects of a true bone anabolic therapeutic agent. We have now shown that the further truncated D2DFosB isoform recapitulates the phenotype of DFosB in bone....

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Pathophysiologic Regulation of FGF-23 in Phosphate Homeostasis: Role of Vitamin D

Investigators: Quan Yuan, PhD, Research Fellow, Michael Densmore, Research Associate
Funder(s): NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Fibroblast growth factor-23 (FGF-23) is a recently identified molecule, which is implicated in the pathogenesis of various human diseases, including in X-linked hypophosphatemia (XLH), oncogenic osteomalacia (OOM), autosomal dominant hypophosphatemic rickets (ADHR), familial tumor calcinosis (FTC), and chronic renal diseases. FGF-23 is one of the most important and...

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Molecular Rationale for the Use of BMP2 in Bone Regeneration

Investigators: Giuseppe Intini, ITI fellow
Funder(s): ITI Foundation

With the major goal of describing the BMP2-dependent molecular mechanisms leading to bone regeneration, Dr. Intini will utilize the Bmp2c/c;Prx1:cre mutant mice, which display a limb specific inactivation of Bmp2, to identify the genetic networks, the signal pathways, and the target genes that are specifically activated in the presence of BMP2. Dr. Intini will take advantage of new molecular technologies such as individual mRNA barcoding, ChIP-on-Chip, and ChIP-seq...

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