Biomedical and Tissue Engineering

Regulation of Xenopus Embryonic Development by TGFbeta

Investigators: Maja Edenius, PhD, research fellow; Chang-Yeol Yeo, PhD, research fellow
Funder(s): NIH/National Institute of Child Health and Human Development

Our long-term goal is to understand how members of the TGFa superfamily act to exert a wide range of cell-type specific actions during development. Our current focus is on the role of TGFa ligands and their primary signal transducers, the Smads, in two sets of developmental events: 1) the regulation of migration of cell populations that establish the craniofacial skeleton and the...

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Multigenic Dissection of Nonsyndromic Oral Clefts

Funder(s): NIH/National Institute of Dental and Craniofacial Research

Cleft lip and/or cleft palate are among the most common birth defects and have serious physical, psychological, and financial consequences for those affected. Nevertheless, little is known about the causes of these anomalies because clefts are the result of genetic and environmental risk factors, rather than a single factor. This research has the potential to make a unique contribution to our understanding of clefts, as it employs novel analytical approaches that allow the simultaneous...

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Development of a New Family of Small Molecule Therapeutics for the Treatment of Chronic Inflammation

Investigators: Maja Edenius, PhD, Research Fellow
Funder(s): Harvard University Technology Development Accelerator Fund

Drs. Whitman and Keller are working as co-principal investigators in collaboration with Anjana Rao, of the Immune Disease Institute at Children’s Hospital Boston. They are developing a new family of small molecule therapeutics for the treatment of chronic inflammatory conditions and autoimmune diseases. 

Established by the Office of the Provost and Office of Technology Development, the Accelerator Fund is...

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Clinical and Radiographic Evaluation of Titanium-Zirconium Narrow-Diameter Dental Implants

Investigators: Goran Benic, DMD, research fellow; Muiz Mokti, DMD, implant resident
Funder(s): ITI Foundation

This multicenter, prospective, controlled, randomized clinical study will compare the outcomes of titanium-zirconium narrow-diameter implants and titanium regular-diameter implants. One study-implant per patient will be placed and restored with a single crown. Outcome parameters will be intraoperative time for the implant bed preparation, dimensions of the residual buccal bone and of the osseous defects immediately after the...

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