Date:
Location:
Dr. Keith Kirkwood
Department of Oral Biology
University at Buffalo, School of Dental Medicine
Session Summary: The adult skeleton is continuously remodeled throughout life through crosstalk between osteoclasts and osteoblasts. Tristetraprolin (TTP) is an RNA-binding protein essential for promoting degradation of target mRNAs, including tumor necrosis factor (TNF), as well as several other immune-associated mRNAs. Myeloid cell subpopulations are key mediators for immune response and bone homeostasis. TTP expression within myeloid tissues is known to decrease with aging. In this session, new evidence for the role of TTP in M-MDSC-induced osteoclastogenesis is presented to understand how this expanded myeloid population may contribute towards the aged-skeletal phenotype.