The Sima Lab research includes basic science investigations into inflammatory pathogenesis of diabetes and periodontitis, and translational approaches to high-resolution diagnostics and phagocyte-targeted therapeutics for non-resolving local and systemic inflammation.
The lab focuses on neutrophil, monocyte and macrophage markers that can predict the onset of periodontitis and insulin resistance, and provide targets for immune modulation therapeutics to resolve inflammation.
Resolution of Inflammation
Resolution of inflammation is an active and coordinated process necessary for structural and functional rehabilitation of inflamed tissues. Resolution is achieved by removal of neutrophils and pro-inflammatory stimuli from the tissues, and the return to basal levels of mononuclear immune cells (macrophages, lymphocytes).
This process is orchestrated by specialized pro-resolving mediators (SPMs) derived from Ω-3 and Ω-6 polyunsaturated fatty acids (PUFAs).
Chronic conditions such as periodontitis, diabetes and cardiovascular disease are associated with altered resolution programs and sustained inflammation in periodontal tissues, central metabolic organs and arterial walls.
The lab investigates means to diagnose and therapeutically address the lost ability to resolve inflammation.