Clinical Sciences

Calcitonin Regulation of Osteoclast Integrin Functions

Funder(s): NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Calcitonin (CT) is the most potent and rapidly acting known inhibitor of bone resorption that targets the osteoclast (OC) directly. CT was the first therapeutic agent used to inhibit excessive bone resorption in osteoporosis and other conditions. It is still used, and new formulations for treating osteoarthritis and osteoporosis are currently in development, despite the fact that a reported loss of efficacy with time has somewhat limited clinical use. Thus, new information about the...

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