Molecular Rationale for the Use of BMP2 in Bone Regeneration

Investigators: Giuseppe Intini, ITI fellow
Funder(s): ITI Foundation

With the major goal of describing the BMP2-dependent molecular mechanisms leading to bone regeneration, Dr. Intini will utilize the Bmp2c/c;Prx1:cre mutant mice, which display a limb specific inactivation of Bmp2, to identify the genetic networks, the signal pathways, and the target genes that are specifically activated in the presence of BMP2. Dr. Intini will take advantage of new molecular technologies such as individual mRNA barcoding, ChIP-on-Chip, and ChIP-seq analyses. The discovery of the molecular mechanisms associated with the activation of BMP2 will suggest novel strategies for bone regeneration therapies whereby BMP2 may be administered together with other factors such as Platelet-Derived Growth Factor (PDGF) or Platelet-Rich Plasma (PRP). Because BMP2, PDGF, and PRP are presently available to periodontists, oral surgeons, and orthopaedic surgeons the outcome of this study may lead to more effective treatments in orthopaedics and dentistry.