Identification of Specific C-Cbl and Cbl-B Functions in Osteoclasts Biology

Investigators: Fabienne Coury, Research Fellow, principal investigator
Funder(s): Gideon and Sevgi Rodan Fellowship

The Gideon and Sevgi Rodan Fellowship from the International Bone and Mineral Society is given annually to support the research activities of a deserving young investigator in the bone field. Support is a one-year, nonrenewable grant. Dr. Coury received this fellowship based on her work on c-Cbl and Cbl-b, which are two widely expressed mammalian members of a family of adaptor proteins that are involved in various biological processes, ranging from defense against infection to osteoclast biology. The goal of Dr. Coury’s study is to identify specific c-Cbl and Cbl-b functions in osteoclasts biology; in particular, to characterize the differential roles of Cbl-b and c-Cbl in the regulation of RANK and c-Fms expression and signaling and to elucidate the role of Cbl-b and c-Cbl in the differentiation and survival of osteoclasts downstream of these two receptors.