Research Projects in Medical Sciences
Molecular Mechanisms of Temporomandibular Joint Disorders by Use of Genetic and Nongenetic Mouse Models
Faculty: Lin Xu, MD, PhD
Funder(s): The Eleanor and Miles Shore 50th Anniversary Fellowship Program for Scholars in Medicine
The objective of this research study focuses on the pathogenesis of temporomandibular joint disorders (TMJD) that affect millions of people around the world. Dr. Xu has identified two mutant mouse models for TMJD and established a surgically induced mouse TMJD model by partial discectomy. Dr. Xu has been investigating risk factors that are responsible for trauma-induced TMJD by use of these mouse models. Results from these studies will provide information for search of novel therapeutic targets for the prevention and treatment of TMJD.