Whitman Laboratory

Malcolm R. Whitman , PhD, Professor of Developmental Biology

Our laboratory is interested in how cellular signals regulate biological responses to disease, damage, or stress within an organism, and how these same cellular signals effect the formation and movement of tissues within a developing embryo. A major lab focus is defining the molecular basis for the specificity of ligands of the TGFß superfamily during the processes of disease, tissue regeneration, and embryonic patterning. TGFßs are critical regulators of inflammation and autoimmunity, wound healing, muscle and bone maintenance, tumor cell behavior, and embryonic patterning. Many of these activities are important potential targets for pharmacotherapy. Our long-term goal is to establish the molecular basis for the specificity of clinically important responses to TGFß, making possible new approaches to disease therapy through signal inhibition.

Personnel

Instructor
Tracy Leigh Keller

Postdoctoral research fellows
Chang-Yeol Yeo
Mattia Bordoli

Research assistant
Grace Lin
Yeonjin Kim