Mohammed Shawkat Razzaque, MD, PhD
Dr. Mohammed Razzaque received his MD degree from the Chittagong University, Bangladesh, and earned his PhD degree from Nagasaki University, Japan, in 1994, becoming a faculty member in the Department of Pathology at Nagasaki University School of Medicine. Dr. Razzaque was involved in reporting surgical pathology and conducting basic research to understand molecular mechanisms of wound healing, emphasizing the roles and regulation of heat shock protein 47 (HSP47) in fibrogenesis. In 1999, Dr. Razzaque came to the United States to work with Dr. Barbara Miller of Pennsylvania State College of Medicine, and one year later joined the Department of Oral Medicine and Diagnostic Sciences, chaired by Dr. Stephen Sonis, at HSDM. Dr. Razzaque’s current research focuses on understanding renal regulation of phosphate metabolism, emphasizing the endocrine actions of the fibroblast growth factor (FGF23)-klotho axis.
Dr. Razzaque has published more than 100 papers in prestigious medical journals, authored multiple books, and has served on the editorial boards of several journals, including the American Journal of Nephrology.
Fields of Interest
After completing his PhD, over the last 16 years Dr. Razzaque has made important contributions in understanding the roles and regulation of HSP47 in fibrogenesis, involving lung, eye, skin, and, kidney. In addition, Dr. Razzaque has shown the significance of reducing GH-IGF1 pathway and caloric restriction in prolonging mammalian survival. Dr. Razzaque’s study is instrumental in determining the significance of “phosphate toxicity” in vascular calcification, a fatal complication, frequently observed in patients with chronic kidney diseases.