Francesca Gori, PhD
Instructor in Oral Medicine, Infection, and Immunity
Francesca Gori, PhD
Dr. Francesca Gori received her PhD in biology from the University of Florence, Italy. Upon receiving her degree, Dr. Gori joined the group of Larry Riggs at the Mayo Clinic as a postdoctoral fellow. During that time, she investigated how hormones and growth and differentiation factors influence bone marrow stromal cell commitment and differentiation. Dr. Gori then decided to pursue a career in basic research in the United States and joined the Endocrine Unit at the Massachusetts General Hospital in 1999.
In 2000, she became an instructor in medicine and in 2005 was promoted to assistant professor in medicine at Harvard Medical School. Her work focused on identifying genes regulated during BMP-2 induction of the chondrocyte and osteoblast phenotype. In collaboration with Dr. Marie Demay, Dr. Gori identified a novel gene, Wdr5, which is a critical component of a complex required for chromatin modifications associated with activation of gene expression and has a crucial role in chondrocyte and osteoblast differentiation. Dr. Gori’s research currently focuses on investigating the role of Wdr5 in bone biology using genetically manipulated mice, osteoblastic and chondrocytic cell lines, and chicken embryos. For this work, she was awarded the Harold Frost Young Investigator Award of the American Society of Bone and Mineral Research (ASBMR) in 2005 and the John Haddad Young Investigator Award of the Advances in Mineral Metabolism (AIMM) in 2007.
In 2011, Dr. Gori joined the Baron Laboratory in the Department of Oral Medicine, Infection, and Immunity at HSDM.
Fields of Interest
Dr. Gori has a longstanding interest in studying the cellular and molecular pathways underlying cell fate and differentiation. Her current research focuses on the identification and characterization of genes that regulate bone development and homeostasis as potential therapeutic targets.